Versatile method for AFM-tip functionalization with biomolecules: fishing a ligand by means of an in situ click reaction.
نویسندگان
چکیده
A facile and universal method for the functionalization of an AFM tip has been developed for chemical force spectroscopy (CFS) studies of intermolecular interactions of biomolecules. A click reaction between tripod-acetylene and an azide-linker-ligand molecule was successfully carried out on the AFM tip surface and used for the CFS study of ligand-receptor interactions.
منابع مشابه
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ورودعنوان ژورنال:
- Nanoscale
دوره 7 15 شماره
صفحات -
تاریخ انتشار 2015